Chitosan Capsule in Mandi Bahauddin

Weight loss is one of the most recognized benefits

High Blood Pressure

Researchers have been studying chitosan as a binding agent for table salt for the management of high blood pressure (hypertension).

In two trials of 81 patients with prehypertension or moderate hypertension, taking a specific product (Symbiosal) with 3% chitosan in table salt for 8 weeks decreased systolic blood pressure, compared with table salt alone

) Weight Loss

Chitosan forms connective films, attaching to bile and fatty acids in the gut. The films then pass through your digestive system, potentially increasing the amount of fat removed in the stool 

In one clinical study, chitosan supplements reduced participants’ weight by up to ~7 lbs over three months. But the placebo alone helped people lose up to 4 lbs. In turn, chitosan’s realistic contribution was only about 3 lbs (1.36 kg), on average 

A Cochrane database review included 15 clinical trials of 1,219 total participants. Chitosan supplementation slightly improved weight loss (-1.7 kg on average). However, this review failed to confirm increased fat excretion. The authors concluded that “the effect of chitosan on body weight is minimal and unlikely to be of clinical significance” 

Even if chitosan did bind and remove dietary fats, there’s a potential downside to this effect. By attaching to and enhancing the removal of excess fats, it may also increase the elimination of important minerals such as calcium and fat-soluble vitamins like vitamin D and vitamin A 

Further clinical trials should investigate the long-term safety and efficacy of chitosan supplements for weight loss.

4) High Cholesterol

According to a review of human studies, adding chitosan to a regular diet can lower total blood cholesterol levels by ~6-40% and LDL cholesterol levels by 15 – 35%.

In one trial of 84 women, chitosan worked to lower total cholesterol levels better than the placebo. In a subgroup of women over 60 years of age, it also reduced LDL and total cholesterol [

On the other hand, chitosan failed to improve cholesterol levels in three studies of 247 participants in the absence of dietary changes 

It may be a safe option for people with borderline-high cholesterol levels, along with appropriate dietary and lifestyle changes. More research is needed.

5) Kidney Disease

Chitosan supplements may help people with kidney disease or kidney failure, but the research to-date is sparse.

In one older trial, chitosan given to 40 people with kidney failure improved strength, appetite, and sleep after 12 weeks. It also increased hemoglobin and reduced blood creatinine and urea levels, which points to its potential to improve kidney function.

Additionally, high phosphorus levels are strongly linked with a higher risk of dying in people with chronic kidney disease. In rats, an iron-chitosan complex reduced blood phosphorus levels. This complex can bind phosphorus stronger than most other available phosphorus binders.

Chitosan Chewing Gum

Chewing chitosan gum also became a popular method for reducing high phosphate levels in people with kidney disease.

However, chitosan gum is not as good as it sounds. In fact, it is probably downright ineffective.

One 2009 study found that chitosan gum lowered phosphate levels after just two weeks of chewing. Recent studies failed to replicate the results.

It turns out that the amount of chitosan in chitosan chewing gum is too low to have a phosphate-binding effect. And according to a detailed analysis, the 2009 study was poorly designed, while the benefits boil down to a placebo effect.

6) Oral Health

More recently, chitosan found its way into dentistry and oral health.

It can be formulated into products for fighting cavities and boosting oral health. Some people chew chitosan gum to prevent or reduce gum inflammation, though no studies confirmed their effectiveness.

In one clinical study, a chitosan mouth-rinse reduced plaque build-up and bacterial growth that leads to gum disease.

Chitosan’s microbe-fighting effects in humans are still an active area of research.

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